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Regarding the central mechanism of feeding regulation, proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus are key anorexigenic neurons
Patients have reported: Increased cramping during the first few months of treatment
so, someone believes this is at least worthy of mentioning to patients to be aware of
In some cases, adjusting the dose, allowing more time for adaptation, or addressing contributing factors may resolve the issue
A deficit of 500 calories per day produces about 1 pound of fat loss per week
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