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S., & Pienta, K

2.4 Metabolic and mitochondrial dysfunction in diabetes An animal experiment using db/db mice, a model of type 2 diabetes, demonstrated that disturbances in circulatory metabolism and brain energy metabolism, particularly mitochondrial dysfunction, may contribute to cognitive impairment

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Interestingly, the effects of GLP-1R agonists have also been studied in non-obese patients without T2DM

Initiation of semaglutide therapy Patient Profile 56-year-old female Hgb A1C 8% Blood pressure 138/86 Fasting glucose 150 Social/ Lifestyle history Single/ Lives alone Sedentary work The diet contains significant amounts of processed foods No regular physical activity (I try to go for a walk some days at lunch time) High School graduate Chief Complaint: Im having a hard time controlling my blood sugar levels