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Animal toxicology data from Sikiric's group showed no LD50 (median lethal dose) could be established in rats, suggesting a wide therapeutic index 31
Normal supplement doses do not show negative interactions
Glutathione is one of the bodys most important antioxidants, helping protect cells from oxidative stress, support detoxification pathways, and promote overall wellness
In summary, oxidative stress and mitochondrial damage may be involved in the development of insomnia, and senegenin exerts neuroprotective effects by regulating oxidative stress and mitochondrial damage through the Keap1/Nrf2 and PINK1/Parkin pathways and shows a clear doseresponse relationship
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