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AAV vectors are generally safe at therapeutic doses eight AAV-based gene therapies have been FDA-approved as of 2024 but at high doses, above roughly 10^14 viral genomes per kilogram, the literature documents immune reactions, liver toxicity, and in rare cases, genotoxicity
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A retrospective study analysed data on the use of acetyl-l-carnitine as an add-on treatment in 137 adult patients with fibromyalgia with pain lasting for over 3 months
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