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A plausible explanation could be a reorientation of Lys105 towards GS resulting in a decreased stabilization of the active site thiolate as a leaving group
Watanabe M, Nakano K, Matsunari H, Matsuda T, Maehara M, Kanai T, et al
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The patients PBM may initially receive an adjudicated GLP-1 prescription claim for weight loss and deny the claim since it does not meet their prior authorization criteria
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