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Mental health concerns, including anxiety and depression, especially with semaglutide, were also notable but occurred less often than GI symptoms, with Wegovy showing the highest depression mention rate

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Future research is also needed to explore the antidepressant effects of LAC acting as part of a system network with other important mediators of brain plasticity in comparison with classical antidepressant drugs with particular focus on the effects in specific phenotypes of depression well-characterized not only for the individual endogenous levels of LAC but also for the corresponding changes in metabolic and inflammatory pathways as well as for history of adverse childhood experiences