A 5mg vial reconstituted with 2ml bacteriostatic water at a starting dose of 2.5mg weekly provides four weeks of doses, perfectly matching the 28-day optimal stability window
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They also diminish appetite and cravings, aiding in blood sugar control and weight loss
For injectable semaglutide: Unopened pens should be stored in the refrigerator
Clinicians should evaluate for contraindications specific to GLP-1 receptor agonists, including: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis or gallbladder disease Severe gastroparesis or gastrointestinal disease History of suicidal ideation or behavior Pregnancy or planned pregnancy (pregnancy testing when appropriate) Diabetic retinopathy (requires monitoring in patients with diabetes) Baseline investigations should include TSH, free T4, complete metabolic panel, lipid profile, and hemoglobin A1c (if diabetic or prediabetic)