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Rizwan Minhas, MD Last reviewed: June 2026 About our review process Tirzepatide is the active ingredient in two prescription products available in Canada: Mounjaro (since November 2022) and Zepbound (since July 2025)
Over 50% of patients find pain manageable with proper technique, because factors like injection speed, needle angle, and injecting a warmed rather than refrigerated pen materially change the immediate sensation
Reported EC values for MT-II in transfected cell assays fall in the sub-nanomolar to low-nanomolar range at MC1R and MC4R, roughly an order of magnitude weaker at MC3R and MC5R, and it is essentially inactive at MC2R, the adrenocorticotropin receptor
10.1016/j.preteyeres.2003.12.001 48 OstwaldP.GoldsteinI
That is an important framing for anyone tempted to treat it as a shortcut: even in the animal work that generates the interest, the compound is one input alongside energy balance, not a replacement for it
