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One major problem, however, is that the histopathological diagnosis itself is not based upon the search of a single (or a few), objective, and easily reproducible morphological diagnostic feature(s) but rather, it is born by a constellation of diagnostic criteria whose implementation, meaning, and relative weight considerably vary case by case and is responsible for a worrisome list of diagnostic pitfalls ( Table 1 )

Higgins JPT TJ, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor

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When the medication cannot bind to these receptors, it cannot do its job of regulating appetite or blood sugar