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In naturally aged mouse models (1820 months old), daily oral administration of 5-amino-1mq capsules for 12 consecutive weeks significantly reduced NNMT activity and increased NAD+ levels in various tissues (liver, kidney, adipose tissue), along with markedly elevated expression of SIRT1 and SIRT3 proteins
A less than optimal production of red blood cells may lead to a lowered oxygen carrying capacity of the blood, resulting in insufficient muscle perfusion
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This is known as hypercobalaminemia
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