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However, they also appear to affect the neural circuits involved in reward and craving

Efficacy and Safety Endpoints Researchers Track Retatrutide trials track endpoints such as percentage body-weight change, HbA1c, waist circumference, lipids, systolic blood pressure, liver fat, adverse events, serious adverse events, and treatment discontinuation [4], [5], [6], [7], [9]

Scientific evidence suggests that these mechanisms may be at least partially overlapping with those regulating food craving and food seeking, he says