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GLP-1 receptor agonists are a class of medications primarily used to manage type 2 diabetes mellitus and, more recently, for weight management in adults with obesity or overweight with weight-related comorbidities

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No effects were seen when glucose was not administered, compatible with the idea that DPP-4 inhibition exerts an anti-hyperglycaemic effect by preventing degradation of endogenously released GLP-1 (26), subsequent studies in glucose-intolerant rodent models did show that the improved glycaemic control following in vivo DPP-4 inhibition was associated with enhanced intact GLP-1 responses to glucose challenges (2729)

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