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Cocaine, methamphetamine, nicotine, alcohol, opioids, converging on a shared mesolimbic mechanism
Indirectly, possibly yes: as GLP-1 medications reduce visceral fat, 11-beta-HSD1 enzyme activity in adipose tissue falls, which lowers active cortisol produced inside fat cells
Additionally, these medications are not recommended for individuals with a history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2
Researched for Preclinical (mouse-only) metabolic research as a selective inhibitor of NNMT (nicotinamide N-methyltransferase)
Kumar points out that theres minimal research on their effects on people with normal weight
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