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Diagnostic delay of more than 6 months contributes to poor radiographic and functional outcome in psoriatic arthritis

A 2025 human pilot study reported no adverse cardiac, hepatic, or renal effects at IV doses of 10-20mg

This effect on mitochondria function includes correcting the cellular energy supply deficit, through facilitating the transport of long chain fatty acid the main source of energy in skeletal muscle into the mitochondria

Compound 38 , containing a (methoxyethyl)pyrazole group, emerged as a successful substitution, enhancing selectivity (pIC 50 for other PDEs 95-fold over other PDEs), and excellent metabolic stability (RLM t 1/2 : 105 min)

Carbohydrates and fats are the biggest culprits