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When To Take High-Dose Vitamin B12 Supplements Treating Vitamin B12 Deficiency People take high-dose vitamin B12 to treat a vitamin deficiency (levels below 200 to 250 pg/mL)
Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)
This means its absorbed faster
Anaphylactic reactions to thiamine are exceedingly uncommon (estimated incidence well below 1 %), but they have been documented
PMID 31244908
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