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Treatment typically begins with 2.5 mg once weekly for 4 weeks, then increases in 2.5 mg increments every 4 weeks as tolerated to the target dose

Dipeptidyl Peptidase IV Inhibition Downregulates Na+ - H+ Exchanger NHE3 in Rat Renal Proximal Tubule

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The aging process is marked by a persistent dysregulation between pro-oxidant and antioxidant mechanisms, resulting in the excessive production of ROS that hinder eNOS functionality, diminish NO bioavailability, and exacerbate endothelial dysfunction (19)