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Lifestyle changes, including diet and exercise, are essential for sustained weight management

The eligibility criteria for most FDA-approved weight loss drugs are as follows: Body mass index (BMI) of 30 or higher (classified as obesity) Body mass index (BMI) of 27 or higher (classified as overweight) with one weight-related health condition, such as hypertension, hyperlipidemia, heart disease, and high blood cholesterol levels

In the food-effect trial, SNAC absorption also appeared to increase following the post-dose meal, particularly at the 4-h meal in the fed and fasting arms (Supplementary Fig