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Among the three antioxidants evaluated in cultured GCs, QUE and SFN induced a statistically significant increase in nuclear activation of the NRF2 protein, as determined by nuclear extract ELISA assays (Figure 1A)

The presence of multiple intracellular signaling systems suggests potential plasticity in GLP-1 action and supports the hypothesis that selective engagement of GLP-1R could preferentially recruit beneficial signaling pathways

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