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Neither will specialized panels used by the Department of Transportation, military, or federal agencies
In response to the concerns noted above that reduce the sensitivity and specificity of serum B12 and confound the diagnosis of B12 deficiency, many investigators now recommend measuring one functional B12 biomarker (serum methylmalonic acid or serum homocysteine) if serum B12 concentrations appear inadequate to ensure a more accurate assessment of B12 status
A separate 2024 meta-analysis (Alshammari et al.) confirmed the same conclusion, further strengthening the evidence base
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Additionally, its ability to optimize energy utilization may help maintain lean muscle mass during weight loss
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