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Arstall MA, Yang J, Stafford I, Betts WH, Horowitz JD
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330,331 Increased glucose uptake by TAMs triggers the hexosamine biosynthetic pathway (HBP), enhancing O-GlcNAcylation of Cathepsin B, which promotes lysosomal secretion and fosters metastasis and chemoresistance
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In simplified terms it works like this: when damage occurs somewhere in the body, the tissue needs blood, oxygen, nutrients, immune cells
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The efficacy of 5-AZA-dC in modulating SSTR2 expression is investigated in several other studies
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