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Glucagon-like peptide-1 receptor agonists and sodiumglucose co-transporter-2 inhibitors as combination therapy for type 2 diabetes: a systematic review and meta-analysis
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10.1016/0304-4165(85)90182-5 Biochim
Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression
Sublingual absorption avoids the stomach entirely, which eliminates the acid and pepsin exposure
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