A major real-world study published in early 2026 led by researchers at Johns Hopkins Bloomberg School of Public Health and analysing electronic health records from approximately 175,000 people with T1D in the US found that those taking GLP-1 drugs had a roughly 15% lower five-year risk of major cardiovascular events and a 19% lower risk of end-stage kidney disease, without any increase in hospitalisation for DKA or severe hypoglycemia
J Aging Res
Pushing a patient past their tolerability threshold often leads to protocol abandonment
For example, a study on the co-encapsulation of astaxanthin and kaempferol demonstrated that, compared to nanoparticles encapsulating astaxanthin alone, the combined formulation exhibited significantly stronger antioxidant activity and lipid-regulating gene expression in RAW264.7 and HepG2 cells, indicating a pronounced synergistic effect (90)
Similarly, ipamorelin decreased CUNS by 20%, reduced the expression of urea cycle enzymes, and improved nitrogen balance, albeit less efficiently than GH