Severe, persistent abdominal pain (especially if radiating to the back), vomiting with inability to keep fluids down for more than 24 hours, or symptoms of gallstones (right upper abdominal pain, jaundice) require urgent medical assessment
It effectively stimulates GH release but it also raises cortisol (stress hormone), prolactin (reproductive hormone), and aldosterone (blood pressure regulator), and produces intense hunger (ghrelin-like appetite stimulation). For researchers, these off-target effects create experimental noise
This represents an improvement over the ~15% weight loss seen over a similar time period in Wegovy clinical trials, though cross trial comparisons are unreliable
Still, athletes are wise to be wary
As with insulin therapies, patient education on proper injection technique and storage is essential