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In contrast, excessive or sustained activation of TLRs can promote chronic inflammation and has been implicated in the pathogenesis of numerous immune-mediated disorders (262)

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J Physiol Pharmacol 60(Suppl 7):115122 Tkalcevic VI, Cuzic S, Brajsa K, Mildner B, Bokulic A, Situm K, Perovic D, Glojnaric I, Parnham MJ (2007) Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression