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They used data from nationwide registries to examine the likelihood ofand reasons fordiscontinuation of semaglutide use for weight loss in all adults (aged 18 or older) without diabetes who initiated treatment between the drug's launch date in Denmark (1 December 2022) and 1 October 2023

sudden drops or no change over 8 weeks should prompt a doctor visit

These may include: A gradual increase gives researchers and clinicians time to monitor tolerability and safety before moving to a higher dose

Second, most clinical trials assessing GLP-1 receptor agonists in liver diseases have relatively short follow-up periods, resulting in limited evidence regarding long-term hepatic outcomes

During the early weeks or after a dose increase, many people feel nausea, lose interest in food, and take in less fluid