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Thus, HDACs are more properly called lysine deacetylases. HDACi induces different phenotypes in various transformed cells, including growth arrest, activation of the extrinsic and/or intrinsic apoptotic pathways, autophagic cell death, reactive oxygen species (ROS)-induced cell death, mitotic cell death and senescence

Low levels of glutathione can lead to a weakened immune system and reduced defense mechanisms against disease

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However, these compounds are associated with Nrf-2-independent adverse effects, which prevented their clinical use despite their beneficial induction of glutathione synthesis