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Research protocols typically employ intermittent dosing strategies (once weekly or 3-day cycles) designed to prevent excessive apoptosis while enabling effective senescent cell elimination, with doses ranging from 5-10 mg/kg body weight in animal studies
This is because it requires conversion to the active form of vitamin B12
Journal of Biological Chemistry , 280(19), 19726-19736
When that happens, the move is not to add more products
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