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Nayan Patel: Humans

An alternative and more quantitative approach would be to directly measure PV/BV using the indicator-dilution method, but that would not be practical in a large-scale, international, multicenter randomized trial, leaving us no viable alternatives to explore this potential mechanism

The Clarke error grid illustrates the difference between blood glucose levels determined by the sensor and the commercial glucose meter (data from 6 rats) (Fig

Potential Side Effects Common Side Effects: Mild flushing Nausea Headache Fatigue Localized irritation at the injection site Serious Side Effects (Seek Immediate Medical Attention): Signs of an allergic reaction (e.g., difficulty breathing, swelling of the face or throat, severe rash) Rapid or irregular heartbeat Severe dizziness or fainting 5

Whether BRP will match semaglutide efficacy in humans remains unknown until clinical trials complete