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While GLP-1 medicines, such as Semaglutide, specifically target the GLP-1 receptor, Tirzepatide targets both the GLP-1 and GIP receptors

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5.3 Diabetic Retinopathy Complications In a pooled analysis of glycemic control trials with RYBELSUS, patients reported diabetic retinopathy related adverse reactions during the trial (4.2% with RYBELSUS and 3.8% with comparator) [see Adverse Reactions (6.1)]