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Weeks 9 to 12 (1.0 mg, 20 units at 5 mg/mL): This is where most people notice significant changes
--- Sources Neeland et al., Changes in lean body mass with GLP-1-based therapies and mitigation strategies , Diabetes, Obesity and Metabolism (2024): Jensterle et al., Rethinking Muscle Health Assessment in GLP-1-Based Therapies for Obesity: Beyond Lean Mass , DOM (2026): Wilding et al., STEP 1 body composition exploratory analysis: LEAN-PREP randomised controlled trial protocol (2025): Function and Lean Mass Preservation With Resistance Exercise During GLP-1RA Treatment, ClinicalTrials.gov: WHO Guidelines on Physical Activity and Sedentary Behaviour: Wegovy Singapore availability and prescription status:
One less common side effect that people often ask a lot about is fatigue
The medication's effects appear consistent across different age groups and baseline weights
The compound is currently in late-stage clinical investigation for obesity and type 2 diabetes
