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-MSH was originally studied for its role in skin pigmentation through activation of melanocortin receptors the same receptor system covered in the PT-141 research overview

17 Typically, the first sign of TAO is ocular surface disease (OSD), although patients may also have eyelid retraction/proptosis, lagophthalmos, periorbital edema and diplopia

doi:10.1001/jama.2013.280490

One study compared EDS patients with a healthy control group to measure passive resistive torque (PRT) of the plantar flexor muscles the muscles that act at the ankle to propel you forward and upward