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Clinicians should conduct a thorough medical history and relevant physical examination for patients with pigmented lesions to identify possible adrenal, gastrointestinal, or genetic disorders that are commonly associated with these types of lesions

Subsequent optimization focused on improving potency by replacing the N-methyl-pyrazole with a 2-methylpyrimidine, yielding Compound 81

First synthesized in the 1980s at the University of Arizona during research on UVindependent pigmentation, Melanotan II peptide is supplied as a highpurity (9899% by HPLC) lyophilized powder for laboratory research applications