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doi: 10.3389/fphar.2021.718147 Received 09 June 2021 Accepted 17 November 2021 Published 13 December 2021 Volume 12 - 2021 Edited by Fan Jiang, Shandong University, China Reviewed by Dechang Chen, Shanghai Jiao Tong University, China Ying Li, Xian Jiaotong University, China Updates Copyright 2021 Tepes, Gojkovic, Krezic, Zizek, Vranes, Madzar, Santak, Batelja, Milavic, Sikiric, Kocman, Simonji, Samara, Knezevic, Barisic, Lovric, Strbe, Kokot, Sjekavica, Kolak, Skrtic, Seiwerth, Boban Blagaic and Sikiric

The opened-vial window can never run past the printed expiration date, and any vial that stops looking perfectly clear gets discarded no matter what the calendar says