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NICE guidance Langendonk JG, Balwani M, Anderson KE, et al

At moderate oxidative stress this effect small

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Because of this rapid enzymatic degradation, native oral glutathione was found to have a baseline bioavailability of less than 1%, and a plasma half-life of roughly two minutes

Also, very small amounts are stored in body tissues and excess riboflavin is flushed out of the body with urine