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GLP-1s are incretin-based agents that amplify glucose-stimulated insulin secretion, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety

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When medication potency decreases, patients with type 2 diabetes may experience inadequate glycemic control, with blood glucose levels rising above target ranges

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Digestive Issues The most common side effects caused by GLP-1 drugs are those affecting the gastrointestinal tract: Nausea Vomiting Diarrhea Constipation Bloating They arise due to the slowing down of food transit from the stomach into the small intestine