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With increasing concern over adverse events across the class, liver safety, cardiovascular outcomes, PK and PD stability, and dose optimized adherence will decide which assets rise to best in class status
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It is contraindicated in certain conditions such as active malignancy and must be used cautiously in those with diabetes, prediabetes, or a history of pituitary disease, which is why careful screening and regular monitoring are essential
Where positive effects have been observed, the magnitude of weight loss is typically smallgenerally in the range of 0.5-2 kgwhich may not be clinically meaningful for most individuals seeking weight management
As discussed above, PCa develops adaptive resistance to AR-targeting therapy through two distinct groups of mechanism based on AR dependency
