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According to the Summary of Product Characteristics (SmPC) approved by the MHRA, gastrointestinal adverse reactions are typically mild to moderate in severity and tend to diminish over time

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[6] Beyond pigmentary effects, the gray-market literature also describes nausea and facial flushing, spontaneous penile erection (priapism, an MC4R-mediated effect), and occasional systemic reactions such as rhabdomyolysis