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These drugs are homologous (53% and 97% respectively) to natural GLP-1, with the added benefit of resistance to degradation by DPP-4 which enhances their half-life

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Dose reduction as weight targets are reached Phase 3 trial protocols allow dose reduction when a participant's BMI drops to 22 kg/m or below, or when there is perceived excessive weight loss
From a broader standpoint, starting with the 2 mg dose also set the stage for understanding long-term tolerability