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This results in increased NO bioavailability, improved oxidative stress, and enhanced coronary blood flow in diabetic rats [104]
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4.8% (similar between groups) Discontinuation Due to AEs: 12% (CagriSema) vs
NLRP3 inflammasome activation not only results in the maturation and release of pro-inflammatory cytokines IL-1 and IL-18 but also cleaves GSDMD, inducing pyroptosis, which further amplifies the inflammatory signal
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