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The starting dose of semaglutide is 0.25 mg once a week (subcutaneously) for the first 4 weeks
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This selectivity means tanning effects are achieved with limited activation of MC3R, MC4R, and MC5R the receptors responsible for off-target effects such as libido modulation (MC4R), appetite suppression (MC4R/MC3R), and sebaceous gland activity (MC5R)
stopping GLP-1 typically leads to weight regain within 36 months
At minimum: A baseline scan before the first dose, a check at 46 weeks during dose escalation, then monthly scans during active therapy, and a comprehensive 6-month outcome review comparing all parameters to baseline
Glucose, A1C, kidney markers, electrolytes, liver-related tests, lipids, and selected nutritional biomarkers can provide objective information about treatment response and possible complications
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