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Although it was originally developed as a drug for diabetes, several clinical trials showed that Ozempic (semaglutide), in addition to diet and exercise , can help overweight and obese people lose significant weight

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It is possible that these differences are due to the DPP-4 inhibitors blocking the degradation of peptides such as GIP and neuropeptide Y, which exert opposite effects on gastric motility and the central nervous system (CNS) control of appetite [5]