Literature was sourced from ClinicalTrials.gov and relevant scientific databases to compare tirzepatide and semaglutide across weight, glycemic, cardiometabolic, and safety outcomes
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Evidence in Action: What Research Shows Frontiers in Endocrinology reports that GLP-1 receptor agonists influence appetite, glucose regulation, and energy balance through multiple central and peripheral pathways
Despite lots of big lingering questions, many clinicians dont think it actually matters right now how GLP-1 interacts with brain receptors on a cellular level, says Laura Huckins, PhD, an associate professor of psychiatry at the Yale School of Medicine
"These medications have exploded in popularity, and CRNAs need to be prepared to see more patients actively take them," says Micah Walden, DNP, CRNA, a member of the AANA Practice Committee