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Given the huge unmet need and major health challenges, the negative trial results are very disappointing, and a sobering reminder that GLP-1 medicines will not be helpful for every medical condition, Daniel Drucker, an endocrinologist at the Lunenfeld-Tanenbaum Research Institute and a recent winner of the 2025 Breakthrough Prize in Life Sciences for his role in the development of GLP-1 agonists, told DDN