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Improvement was more significant in the oral glutathione treatment groups as compared to the topical, but both treatments were superior to placebo for reduction of MASI score
Reaction products were purified by flash column chromatography on silica gel 60 (230400 mesh, Macherey Nagel) or aluminium oxide (activated neutral, Sigma-Aldrich) using a CombiFlash NextGen System and a preparative HPLC Quaternary Gradient 2545 equipped with a photodiode array detector 2998 (Waters) fitted with a reverse-phase column (XBridge BEH C18 OBD prep column 5 m, 30 150 mm)
Any agent that could increase this rate, even modestly, deserves careful consideration given the severity of major bleeding events in anticoagulated patients
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Group III (10 patients) received oral placebo capsules (as a control) once daily for 4 weeks
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