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The study began by collecting blood samples from the jugular veins of fourth-month old, male Sprague-Dawley rats

Yes, refrigerating an opened vial at 2 to 8C is acceptable and will not damage it

Peer review Peer review information Nature Metabolism thanks the anonymous reviewers for their contribution to the peer review of this work

Quick Comparison Feature CagriSema Retatrutide Development owner Novo Nordisk Eli Lilly Core strategy Combination therapy Single-molecule multi-agonist Pathways Amylin + GLP-1 GIP + GLP-1 + glucagon Main components Cagrilintide + semaglutide Retatrutide (LY3437943) 2026 status Phase 3 / regulatory-watch candidate Phase 3 TRIUMPH program Best-fit research question Can amylin extend GLP-1 results

Understanding optimal food choices during GLP-1 therapy applies equally to tirzepatide-based protocols