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This is distinct from intradiscal injection, which requires fluoroscopy or ultrasound guidance and must be performed by a qualified medical professional

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Buffered NAD+ ships with a pH stabilizer (most commonly Tris) that brings the reconstituted solution closer to physiological pH (~7-8.5), while unbuffered NAD+ reconstitutes acidic (~pH 3-4) and is more often associated with injection-site stinging

The label says to inject right after reconstitution