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This results from a tyramine-induced depletion of norepinephrine normally present in the readily releasable vesicle pool, and replacement of vesicular norepinephrine with tyramine (which functions as a false- or pseudo- neurotransmitter), which when released has no effect on postsynaptic adrenergic receptors (Figure 1)

Weeks 1-4: 2.5 mg once weekly Weeks 58 : 5 mg once weekly Weeks 912 : 7.5 mg once weekly if you can tolerate the previous dosage and further glycemic control is needed Weeks 1316 : 10 mg once weekly, if you have still not reached your target blood sugar levels Weeks 1720 : 12.5 mg once weekly, if needed Week 20 and onwards : 15 mg once weekly, which is the maximum dosage of Mounjaro If you experience side effects, your doctor may delay dosage escalation for the next 4 weeks or lower the dosage of Mounajro

Across studies, patients reported fewer phototoxic events and faster recovery on treatment