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Additionally, evidence from murine models suggests that the accumulation of Treg cells in the liver may promote the progression from MASH to HCC by creating an immunosuppressive microenvironment (132) ( Figure 6A )

Patients with chronic liver disease caused by viral hepatitis (positive serology for hepatitis B or C), excessive alcohol consumption, other causes of chronic liver disease (such as autoimmune hepatitis or hemochromatosis), and those using hepatotoxic drugsincluding glucocorticoids, methotrexate, antiretrovirals, amiodarone, tamoxifen, or estrogenswere excluded