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PT-141 (bremelanotide) is a melanocortin-4 receptor agonist that became FDA-approved in 2019 for premenopausal HSDD based on the RECONNECT Phase 3 trials (Kingsberg et al

The peptide activates neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons in the arcuate nucleus, which drive feeding behavior

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However, for larger SNAC concentrations, deviations from a simple 1:1 binding model were observed, which is consistent with the formation of larger, dynamic SNAC aggregates that are also observed in DLS (Fig