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Zixin Y et al (2022) TMAO as a potential biomarker and therapeutic target for chronic kidney disease: a review
The treatments included EGCG-Zn nanocomposite suppositories (100/25 mg/kg), EGCG (100 mg/kg), Zn (25 mg/kg), a physical mixture of EGCG and Zn (100/25 mg/kg), and a blank suppository base
This lipidation promotes albumin binding, extending its plasma half-life to approximately one week, which allows for once-weekly dosing
A tablet is not automatically a step down from an injection, and it is not automatically easier
newer formulations (e.g., liposomal) may have better absorption but still need evidence
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